Selected Recent Publications
Lee, P., K. Wang, C.E. Woods, P. Yan, P. Kohl, P. Ewart, L.M. Loew, D.A. Terrar, and C. Bollensdorff. 2012. Cardiac electrophysiological imaging systems scalable for high-throughput drug testing. Pflugers Arch. in press.
Yan, P., C.D. Acker, W.L. Zhou, P. Lee, C. Bollensdorff, A. Negrean, J. Lotti, L. Sacconi, S.D. Antic, P. Kohl, H.D. Mansvelder, F.S. Pavone, and L.M. Loew. 2012. A palette of fluorinated voltage sensitive hemicyanine dyes. Proceedings of the National Academy of Sciences of the United States of America, in press.
Falkenberg, C. and L. M. Loew. 2012. Computational analysis of Rho GTPase cycling. PLoS Computational Biology, in press.
Brown, S.A., and L.M. Loew. 2012. Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia. BMC Syst Biol. 6:70.
Lee, P., F. Taghavi, P. Yan, P. Ewart, E.A. Ashley, L.M. Loew, P. Kohl, C. Bollensdorff, and C.E. Woods. 2012. In situ optical mapping of voltage and calcium in the heart. PLoS ONE. 7:e42562.
Loew, L.M. 2012. Biophysical Journal 60 years after Hodgkin-Huxley. Biophysical journal. 103:E1-2.
Michalski, P.J., and L.M. Loew. 2012. CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximation. Phys Biol. 9:036010.
Lee, P., P. Yan, P. Ewart, P. Kohl, L.M. Loew, and C. Bollensdorff. 2012. Simultaneous measurement and modulation of multiple physiological parameters in the isolated heart using optical techniques. Pflugers Arch. 464:403-414.
Leao, R.N., S. Mikulovic, K.E. Leao, H. Munguba, H. Gezelius, A. Enjin, K. Patra, A. Eriksson, L.M. Loew, A.B. Tort, and K. Kullander. 2012. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nature neuroscience. 15: 1524-1530.
Ditlev, J.A., P.J. Michalski, G. Huber, G.M. Rivera, W.A. Mohler, L.M. Loew, and B.J. Mayer. 2012. Stoichiometry of Nck-dependent actin polymerization in living cells. The Journal of Cell Biology. doi: 10.1083/jcb.201111113.
Sacconi, L., C. Ferrantini, J. Lotti, R. Coppini, P. Yan, L.M. Loew, C. Tesi, E. Cerbai, C. Poggesi, and F.S. Pavone. 2012. Action potential propagation in transverse-axial tubular system is impaired in heart failure. Proceedings of the National Academy of Sciences of the United States of America. 109: 5815–5819.
Cowan, A.E., Moraru, II, J.C. Schaff, B.M. Slepchenko, and L.M. Loew. 2012. Spatial modeling of cell signaling networks. Methods Cell Biol. 110:195-221.
Acker, C.D., P. Yan, and L.M. Loew. 2011. Single-voxel recording of voltage transients in dendritic spines. Biophysical journal. 101:L11-L13.
Ditlev, J.A., N.M. Vacanti, I.L. Novak, and L.M. Loew. 2009. An open model of actin dendritic nucleation. Biophysical journal. 96:3529-3542.
Brown, S., F. Morgan, J. Watras, and L.M. Loew. 2008. Analysis of phosphatidylinositol-4,5-bisphosphate signaling in cerebellar Purkinje spines. Biophysical journal. 95:1795-1812.
Honors, Awards, and Professional Activities
Phi Beta Kappa; NSF Trainee, 1969-73, Nehemiah Gittelson Medal; NIH Research Career Development Award, 1980-85; American Chemical Society; Biophysical Society; AAAS. Editorial Boards: Biophysical Journal, Journal of Fluorescence, Cell Biophysics & Biochemistry; Chair NIH MABS Study Section, 2004-2006; Boehringer Ingelheim Chair in Cell Sciences; Elected to Connecticut Academy of Science and Engineering, 2008. Editor-in-Chief, Biophysical Journal, 2012-2017.
Sapia, M. A., J. C. Schaff, I. R. Greenshields, L. M. Loew, and F. R. Morgan (2000) “Method and apparatus for three-dimensional deconvolution of optical microscope images,” United States Patent 6,166,853.
Schaff, J. C., J. Carson and L. M. Loew (2001) “Method and apparatus for modeling cell structure and function,” United States Patent 6,219,440.
Schaff, J. C., J. Carson and L. M. Loew (2004) “Method for modeling cellular structure and function,” United States Patent 6,708,141.
Loew, L.M. and Yan, P. (2012) “Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use,” United States Patent 8,129,532 B2.
Arkady M. Pertsov, Arvydas Matiukas, Leslie M. Loew, and Joseph P. Wuskell (2012) “Composition, method, system, and kit for optical electrophysiology” United States Patent 8,155,730