| Faculty | Post-Docs | Grad Students | Staff |
 Biology: My general research interests center on understanding signal transduction mechanisms, in particular related to calcium and phosphoinositides. Examples are quantitative experimental and modeling studies of signaling networks in neuronal cells, such as the nonlinear response and spatial modulation of calcium signaling, and the regulation of IP3 receptor activity. Computer Science: My general interest is focused on the design and development of computational cell biology software tools geared towards the biologist, non-mathematical expert, user. I have been involved since 1998 in theVirtual Cell project, and I am currently responsible for the design and development of the biological user interface and data export and analysis tools. Another recent project, in collaboration with Bill Mohler, is automated and/or interactive processing and VR visualization of 4D fluorescence microscopy data (gene expression during C. elegans embryonic development). I oversee our Computational Facility, which provides High Performance Computing support to the National Center for Cell Analysis and Modeling, the Technology Center for Polarity in Networks and Pathways, the CCAM Microscopy Facility, and other research projects of individual CCAM faculty members. Selected Publications C.A. Mannella, D.R. Pfeiffer, P.C. Bradshaw, I.I. Moraru, B. Slepchenko, L.M. Loew, C.E. Hsieh, K. Buttle, and M. Marko. Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications, IUBMB Life (2001) 52:93-100. I.I. Moraru, J.C. Schaff, B.M. Slepchenko, and L.M. Loew. The Virtual Cell: An Integrated Modeling Environment for Experimental and Computational Cell Biology, Ann. NY Acad. Sci. (2002) 971: 589-594. J. Wagner, C.P.Fall, F. Hong, C.E. Sims, N.L. Allbritton, R.A. Fontanilla, I.I. Moraru, L.M. Loew, and R. Nuccitelli. Wave of IP3 production accompanies the fertilization Ca2+ wave in the egg of the frog, Xenopus laevis: theoretical and experimental support, Cell Calcium (2004) 35:433-447. I.I. Moraru and L.M. Loew. Intracellular signaling: Spatial and Temporal Control, Physiology (2005) 20, 169-179.
Honors 1981 Third Prize, International Mathematical Olympiad (USA) 1985-88 National Scholarship (Romania) 1986 Senate Award, National Conference on Student Medical Research (Davila University) 1988 Mariana Constantinescu Memorial Award for Medical Excellence (Davila University) 1991-93 John E. Fogarty Research Fellowship (NIH) 1996 Young Investigator Award, Scientific Conference on the Molecular Biology of the Normal, Hypertrophied, and Failing Heart (AHA)
|
||||||||||||||||||||
 |
 |
 |