Research Interests

The Virtual Cell Project. Since my emigration to the U.S. in 1996, I have been working on the Virtual Cell project at CCAM. As a member of a "mathematics team" (also J. Schaff (CCAM), Y. S. Choi (UConn, Storrs), and D. Resasco (Yale)), I am responsible for the subproject Mathematical and Physical Analysis of Cell Biological Processes. I am involved in modeling that is required for the experimental subprojects on calcium dynamics and RNA trafficking and for collaborative projects. I also participate in the development and validation of numerical techniques.

Awards

Award of the International Science Foundation (Soros Foundation) for scientists in the former Soviet Union.

Selected Publications

Slepchenko, B. M. 1981. On the theory of antiferromagnetism. Topics in Solid State Physics Series, Chelyabinsk, pp. 59-63.

Slepchenko, B. M. 1982. Spatial correlation of charge density fluctuations in the ground state of the one-dimensional Hubbard model in the strong interaction limit. Phys. Met. Metall. 53: 33-37.

Slepchenko, B. M. 1982. Correlation of charge density fluctuations in the Hubbard model in the strong interaction range. Phys. Met. Metall. 54: 184-188.

Slepchenko, B. M. 1984. Correlation of density fluctuations and the metal-insulator transition in the one-dimensional spinless fermion model. Phys. Met. Metall. 57: 34-44.

Slepchenko, B. M. 1985. Temperature-induced metal-insulator transitions in the Hubbard model. Phys. Met. Metall. 59: 1-7.

Slepchenko, B. M. 1986. Metal-insulator temperature transitions in the Hubbard model. Phys. Met. Metall. 62: 44-51.

Slepchenko, B. M. 1988. Charge carriers in the Hubbard antiferromagnet. Sov. J. Phys. 31: 50-56.

Bryzgalov, A. N., Yermolayev, V. S., Kolenko, A., Musatov, V. V., Slepchenko, B. M. 1989. A method of forming single crystals of quartz. Patent. SU No. 1550943-A1.

Bryzgalov, A. N., Slepchenko, B. M., Virachev, B. P. 1989. Features of Gadolinium Molibdate single crystal domain structure. Sov. J. Phys. 32: 111-113.

Bryzgalov, A. N., Slepchenko, B. M., Virachev, B. P., Musatov, V. V., Romanova, G. I. 1989. Effect of microstructure of polycrystalline ZnS on its optical properties. News of Acad. Sci. USSR: Inorg. Mat. 25: 1430-1433.

Slepchenko, B. M., Bryzgalov, A.N., Aksenovskikh, A. Ya., Musatov, V.V., Romanova, G. I. 1990. Influence of grain boundaries on attenuation of a radiation flux in polycrystalline ZnSe samples. Sov. Phys. Sol. State, 36: 375-376.

Bryzgalov, A.N., Slepchenko, B. M., Aksenovskikh, A. Ya., Musatov, V. V., Khalilov, L. M. 1991. Structure and optical properties of polycrystalline ZnSe. News of Acad. Sci. USSR: Inorg. Mat. 27: 1176-1179.

Slepchenko, B. M. 1992. Effective hole attraction in the Hubbard model. Superconductivity: physics, chemistry, technology. 5: 2181-2186.

Slepchenko, B. M. 1994. Ground state of the extended Hubbard model with attraction at neighboring sites. Low Temp. Phys. 20: 168-174.

Schaff, J., Fink, C. C., Slepchenko, B., Carson, J. H., and Loew, L. M. 1997. A general computational framework for modeling cellular structure and function. Biophys. J. 73: 1135 - 1146.

Choi, Y. S., Resasco, D., Schaff, J., Slepchenko, B. 1999. Electrodiffusion of ions inside living cells. IMA Journal of Applied Mathematics. 62: 207-226.

Fink C. C., Slepchenko B., and Loew L. M. 1999. Determination of Time-Dependent Inositol-1,4,5-Trophosphate Concentrations during Calcium Release in Smooth Muscle Cell. Biophys. J. 77: 617 - 628.

Fink, C. C., Slepchenko, B., Moraru, I. I., Schaff, J., Watras, J., and Loew, L. M. 1999. Morphological Control Of Inositol-1,4,5-Triphosphate-dependent Signals. J. Cell Biol. 147: 929-935.

Fink, C. C., Slepchenko, B., Moraru, I. I., Schaff, J., Watras, J., and Loew, L. M. 2000. An image-based model of calcium waves in differentiated neuroblastoma cells. Biophys. J. 79: 163-183.

Schaff, J. C., Slepchenko, B. M., Loew, L. M. 2000. Physiological modeling with the Virtual Cell framework. In Methods in Enzymology, edited by M. Johnson. (Academic Press, San Diego), v. 321 pp. 1-23.

Slepchenko, B. M., Schaff, J. C., Choi, Y. S. 2000. Numerical Approach to Fast Reactions in Reaction-Diffusion Systems: Application to Buffered Calcium Waves in Bistable Models. J. Comput. Phys. 162: 186-218.

Terasaki, M., Compagnola, P., Rolls, M. M., Stein, P. A., Ellenberg, J., Hinkle, B., and Slepchenko, B. 2001. A new model for nuclear envelope breakdown. Mol. Biol. Cell. 12: 503-510

Schaff J. C., Slepchenko, B. M., Choi, Y.-S., Wagner, J., Resasco, D., and Loew, L. M. 2001. Analysis of nonlinear dynamics on arbitrary geometries with the Virtual Cell. Chaos 11: 115-131.

Slepchenko, B. M., and Bronner, F. 2001. Modeling of transcellular Ca transport in rat duodenum points to coexistence of two mechanisms of apical entry. Am. J. Physiol., Cell Physiology. 281: C270-C281.

Mannella, C. A., Pfeiffer, D.R., Bradshaw, P. C., Moraru, I. I., Slepchenko, B., Loew, L. M., Hsieh, C., Buttle, K., Marko, M. 2001. Topology of the mitochondrial inner membrane: Dynamics and bioenergetic implications. IUBMB LIFE. 52 (3-5): 93-100.

Carson, J.H., Cui, H., Krueger, W., Slepchenko, B., Brumwell, C., and Barbarese, E. 2001. RNA Trafficking in Oligodendrocytes. In Results and Problems in Cell Differentiation, v. 34, pp. 69-81.

Slepchenko, B. M., Schaff, J. C., Carson, J. H., Loew, L. M. 2002. Computational Cell Biology: Spatiotemporal Simulation of Cellular Events, Annu. Rev. Biophys. Biomol. Struct. 31: 423-441.

Smith, A. E., Slepchenko, B. M., Schaff, J. C., Loew, L. M., Macara, I. G. 2002. Systems Analysis of Ran Transport, Science. 295: 488-491.

Hinkle, B., Slepchenko, B., Rolls, M. M., Walther, T. C., Stein, P. A., Mehlmann, L. M., Ellenberg, J., and Terasaki, M. 2002. Chromosomal association of Ran during meiotic and mitotic divisions. J. Cell Sci. 115: 4685-4693.

Moraru, I. I., Schaff, J. C., Slepchenko B. M., and Loew L. M. 2002. The Virtual Cell: An Integrated Modeling Environment for Experimental and Computational Cell Biology. Annals of the New York Academy of Sciences. 971: 595-596.

Bronner, F., Slepchenko, B., Wood, R. J., Pansu, D. 2003. The Role of Passive Transport in Calcium Absorption, Letter to the Editor. J. Nutr. 133: 1426.

Burakov, A., Nadezhdina, E., Slepchenko, B., and Rodionov, V. Centrosome positioning in interphase cells. 2003. J. Cell Biol. 162: 963 - 969.

Slepchenko, B. M. and Terasaki, M. 2003. Cyclin aggregation and robustness of bio-switching. Mol. Biol. Cell. 14: 4695 - 4706.

Slepchenko, B. M., Schaff, J. C., Macara, I., and Loew, L. M. 2003. Quantitative cell biology with the Virtual Cell. Trends Cell Biol. 13: 570 - 576.

Slepchenko, B. M., Terasaki, M. 2004. Bio-switches: what makes them robust? Curr. Opin. Genet. Dev.14/4: 428-434.

Novak, I. L., Slepchenko, B. M., Mogilner, A., Loew, L. M. 2004. Cooperativity between cell contractility and adhesion. Phys. Rev. Lett. 93: 268109-1 - 268109-4.

Hernjak, N., Slepchenko, B. M., Fernald, K., Fink, C. C., Fortin, D., Moraru, I. I., Watras, J., Loew L. M. 2005. Modeling and Analysis of Calcium Signaling Events Leading to Long-Term Depression in Cerebellar Purkinje Cells. Biophys. J.89: 3790-3806.